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KMID : 0360220210620081069
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Journal of the Korean Ophthalmological Society
2021 Volume.62 No. 8 p.1069 ~ p.1075
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Depression, Anxiety, Somatization Disorder, and Adjustment Disorder in Older Patients with Exudative Age-related Macular Degeneration
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Lee Hee-Chul
Nam Hye-Won
Kang Dong-Woo
Yeom Myeong-In
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Abstract
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Purpose: The aim of this study was to analyze the prevalence of depression, anxiety, somatization disorder, and adjustment disorder in older patients diagnosed with exudative age-related macular degeneration (AMD) and to evaluate the relationship between exudative AMD and psychological disease.
Methods: The 2016 Health Insurance Review and Assessment Service-Aged Patient Sample was applied in this study. The
subjects were divided into two groups: AMD patients undergoing intravitreal injection treatment and a control group. Comorbidities were evaluated using the Charlson Comorbidity Index.
Results: A total of 1,319,052 subjects were selected, of which 3,134 were in the exudative AMD group receiving intravitreal injections. The average age of the subjects was 74.7 ± 6.7 years, and 41.8% were male. In patients with exudative AMD, the prevalence of depression, anxiety, somatization disorder, and adjustment disorder were 16%, 20%, 0.5%, and 0.4%, respectively; in particular, the prevalence of depression and adjustment disorder were significantly higher than in the control group.
In multivariate regression analysis, exudative AMD was a significant factor of depression (odds ratio [OR] 1.2, 95% confidence interval [CI] 1.08-1.31, p < 0.001) and adjustment disorder (OR 2.47, 95% CI 1.47-4.18, p < 0.001). However, the association between AMD and anxiety or somatization disorder was not statistically significant.
Conclusions: Exudative AMD showed a significant association with psychiatric disease, such as depression, and requires close clinical attention.
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KEYWORD
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Adjustment disorder, Age-related macular degeneration, Anxiety, Depression, Somatization disorder
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